By-products inhibit yeast and fungi: Pseudomonas aeruginosa

1 of 1 Scanning electron micrograph (SEM) of Pseudomonas aeruginosa bacteria / Janice Haney.. / License

The metabolism of Pseudomonas aeruginosa produces products that inhibit yeast and fungal growth via the conversion of unsaturated fatty acids.

Biomimicry Taxonomy

	Make >
	Chemically assemble >
	Organic compounds

Biomimetic Application Ideas

Develop green chemistry processes for these useful biocompounds based on the bioconversion reactions of PR3.

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[Collapse all sections] Summary

"Bioconversion is a “green” technology that converts fatty acids into entirely new chemical compounds with antimicrobial, industrial or biomedical properties. The bioconversion reactions by Pseudomonas aeruginosa PR3 have been cited extensively among microbial systems that produce mono-, di- and tri-hydroxy fatty acid derivatives from unsaturated fatty acids (Kuo et al., 1998). Strain PR3, isolated from a waste water stream on a pig farm in Morton, IL, USA was found to convert oleic acid to a novel compound, 7,10-dihydroxy-8(E)-octadecenoic acid (DOD), which inhibits the laboratory growth of Candida albicans, a yeast that sometimes causes thrush and other infections in humans (Hou and Bagby, 1991). This strain was also found to convert ricinoleic acid to another novel compound 7,10,12-trihydroxy-8(E)-octadecenoic acid (TOD), which inhibits the rice blast fungus, raising the prospect for a biological fungicide against this pathogen (Kuo et al., 2001). These recently described compounds, from the microbial conversion of unsaturated fatty acids, are potential value-added products that will inhibit such pathogens." (Bajpai et al. 2008:136)

About the inspiring organism

Bacteria
Bacteria

Organism/taxonomy data provided by:
Species 2000 & ITIS Catalogue of Life: 2008 Annual Checklist

Bioinspired products and application ideas

Application Ideas: Develop green chemistry processes for these useful biocompounds based on the bioconversion reactions of PR3.

Industrial Sector(s) interested in this strategy: Medicine, agriculture

Experts

Department of Biotechnology
Vivek K. Bajpai Sun Chul Kanga
College of Engineering, Daegu University

References

Bajpai, Vivek K.; Shin, Seung Yong; Kim, Hak Ryul; Kang, Sun Chul. 2008. Anti-fungal action of bioconverted eicosapentaenoic acid (bEPA) against plant pathogens. Industrial Crops and Products. 27(1): 136-141.

By-products inhibit yeast and fungi: Pseudomonas aeruginosa

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