• Strategy

Bioconverted by-products inhibit yeast and fungi: Pseudomonas aeruginosa


Scanning electron micrograph (SEM) of Pseudomonas aeruginosa bacteria / Janice Haney.. / LicensePD - Public Domain

When external unsaturated fatty acid eicosapentaenoic acid is introduced to bacteria Pseudomonas aeruginosa, eicosapentaenoic acid is bioconverted to a hydroxy fatty acid exhibiting properties that inhibit the growth of yeast and fungi.

"Bioconversion is a “green” technology that converts fatty acids into entirely new chemical compounds with antimicrobial, industrial or biomedical properties. The bioconversion reactions by Pseudomonas aeruginosa PR3 have been cited extensively among microbial systems that produce mono-, di- and tri-hydroxy fatty acid derivatives from unsaturated fatty acids (Kuo et al., 1998). Strain PR3, isolated from a waste water stream on a pig farm in Morton, IL, USA was found to convert oleic acid to a novel compound, 7,10-dihydroxy-8(E)-octadecenoic acid (DOD), which inhibits the laboratory growth of Candida albicans, a yeast that sometimes causes thrush and other infections in humans (Hou and Bagby, 1991). This strain was also found to convert ricinoleic acid to another novel compound 7,10,12-trihydroxy-8(E)-octadecenoic acid (TOD), which inhibits the rice blast fungus, raising the prospect for a biological fungicide against this pathogen (Kuo et al., 2001). These recently described compounds, from the microbial conversion of unsaturated fatty acids, are potential value-added products that will inhibit such pathogens." (Bajpai et al. 2008:136)
About the inspiring organism

Learn more at EOL.org
Organism/taxonomy data provided by:
Species 2000 & ITIS Catalogue of Life: 2008 Annual Checklist

Bioinspired products and application ideas

Application Ideas: Develop green chemistry processes for these useful biocompounds based on the bioconversion reactions of PR3.

Industrial Sector(s) interested in this strategy: Medicine, agriculture

Department of Biotechnology
Vivek K. Bajpai Sun Chul Kanga
College of Engineering, Daegu University
Bajpai, Vivek K.; Shin, Seung Yong; Kim, Hak Ryul; Kang, Sun Chul. 2008. Anti-fungal action of bioconverted eicosapentaenoic acid (bEPA) against plant pathogens. Industrial Crops and Products. 27(1): 136-141.
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