Innovators are full of questions.Nature has answers.


  • Strategy

Biofilms protect bacteria: gram negative bacteria


Biofilm of Staphylococcus aureus bacteria / Janice Carr,.. / LicensePD - Public Domain

Colonies of Pseudomonas aeruginosa bacteria protect themselves from antibiotics and other insults by grouping together and secreting adhesive polysaccharides, forming what is known as a biofilm.

"From the clinical perspective, biofilms are a major problem, since these structures display greatly increased resistance to physical and chemical insults, 7 which is probably a major reason why they form in the first place! Crucially, biofilms are much more resistant to antibiotic treatment than their planktonic counterparts, making them particularly difficult to eliminate from patients and contaminated surgical equipment…One of the main problems with P. aeruginosa infections is that the organism is resistant intrinsically to the action of many antibiotics, a situation that is exacerbated when it forms biofilms." (Welch et al., 2005:197, 199)
About the inspiring organism
Med_800pxstaphylococcus_on_catheter Pseudomonas aeruginosa
Pseudomonas aeruginosa (Schroeter 1872) Migula 1900 (Approved Lists 1980)

Learn more at
Some organism data provided by: BIOS: Bacteriology Insight Orienting System
Organism/taxonomy data provided by:
Species 2000 & ITIS Catalogue of Life: 2008 Annual Checklist

Bioinspired products and application ideas

Application Ideas: Cystic fibrosis. Treatments for drug overdose, toxin exposure.

Industrial Sector(s) interested in this strategy: Medical, pharmacology, industrial

Molecular Cell Biology
Martin Welch
Department of Biochemistry, University of Cambridge
Welch, M.; Mikkelsen, H.; Swatton, J. E.; Smith, D.; Thomas, G. L.; Glansdorp, F. G.; Spring, D. R. 2005. Cell-cell communication in Gram-negative bacteria. Mol Biosyst. 1(3): 196-202.
Learn More at Google Scholar Google Scholar  


Login to Post a Comment.

No comments found.